Mechanical Engineering Graduate Seminar

Thursday, February 23 at 3:30 pm to 4:20 pm
Seamans Center, 2229 SC
103 South Capitol Street, Iowa City, Iowa

"Enabling PTOA Risk Prediction from Pathomechanics in Clinical Practice" presented by Donald D. Anderson, PhD, Professor & Vice Chair of Research, Department of Orthopaedics & Rehabilitation at the University of Iowa. Abstract:  The long-term goal of our research is to forestall post-traumatic osteoarthritis (PTOA), the disabling condition that often develops after joint injuries like an intra-articular fracture (IAF). A primary objective of the group’s present work is to enable the use of innovative methods for assessing IAFs to better inform patient care and to guide future clinical trials. IAFs initiate a sequence of cellular-level events involving metabolic impairment that triggers progressive joint degeneration. Strong evidence is emerging that new biologic agents could mitigate or arrest these events, offering hope for a paradigm shift in treating IAFs, but controlled clinical trials are urgently needed. We have developed capabilities to predict PTOA risk using CT-based measures of pathomechanical factors associated with IAFs (fracture severity and elevated contact stress post-treatment), but critical barriers remain to enabling PTOA risk prediction from pathomechanics in clinical practice. I will present the group’s work toward forestalling PTOA by: (1) expanding prior work to develop objective predictors of PTOA risk and (2) laying the foundation for a platform incorporating accurate severity and contact stress assessment as a centerpiece of treatment decision-making and future clinical trials. Individuals with disabilities are encouraged to attend all University of Iowa sponsored events. If you have a disability that requires an accommodation in order to participate in this program, please call the department  in advance, at 335-5939.

Contact Info: MIE Office,, 319-335-5939